BACKGROUND: platelet-rich plasma autologous (PRPA) awakens more and more the interest of different medical specialties, including Dermatology, due to his demonstrated ability to accelerate wound healing, contribute to the permanence of Follicular units after transplantation, increase the density of the hair in the treatment of androgenetic alopecia and hair contribute to epidermal rejuvenation. It has been proposed that the factors of
OBJECTIVE: to evaluate histopathologic changes in thefollicular units of a sample of subjects with androgeneticalopecia, before and after local application of autologousplatelet-rich plasma.
MATERIAL and method: experimental study which included20 subjects with androgenetic alopecia; autologousplatelet-rich plasma was applied to 17 and 3 were chosenat random to receive placebo.
(Placebo or autologous platelet-rich plasma) treatmentswere administered intradermally twice a week for threeweeks (six in total applications) on the right side of thehaired skin.
RESULTS: no significant difference was observed in thenumber, thickness, and level of follicles or the relationshipanagen catagen before and after the application ofautologous platelet-rich plasma, or to compare thesefindings between the group that received plasma rich in
platelets autologous and which received placebo.
CONCLUSIONS: because of subjects evaluated sample wassmall and that time tracking was short, cannot concludedefinitively whether the local application of three-weekautologous platelet-rich plasma is effective or not asmethod therap eutychus from androgenetic alopecia, so itis important to study the long term with a greater numberof subjects.